InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Trex1

Summary

InnateDB Protein

IDBP-538563.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Trex1

Protein Name

three prime repair exonuclease 1

Synonyms

1661; AU041952;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000118499

InnateDB Gene

IDBG-201128 (Trex1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0003690	double-stranded DNA binding
GO:0003697	single-stranded DNA binding
GO:0008408	3'-5' exonuclease activity
GO:0032405	MutLalpha complex binding
GO:0032407	MutSalpha complex binding
GO:0032558	adenyl deoxyribonucleotide binding
GO:0042803	protein homodimerization activity

Biological Process

GO:0035458	cellular response to interferon-beta
GO:0090305	nucleic acid phosphodiester bond hydrolysis

Cellular Component

Protein Structure and Domains

PDB ID

MGI:1328317

InterPro

IPR012337 Ribonuclease H-like domain

PFAM

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

PhosphoSite-

TrEMBL

D3YUE0

UniProt Splice Variant

Entrez Gene

22040

UniGene

Mm.467431

RefSeq

MGI ID

MGI Symbol

Trex1

OMIM

CCDS

HPRD

IMGT

EMBL

AC140383

GenPept