Version 5.4
Mus musculus Protein: Tmprss11e
Summary
InnateDB Protein IDBP-538703.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Tmprss11e
Protein Name transmembrane protease, serine 11e
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000124534
InnateDB Gene IDBG-175487 (Tmprss11e)
Protein Structure
UniProt Annotation
Function Serine protease which possesses both gelatinolytic and caseinolytic activities. Shows a preference for Arg in the P1 position. {ECO:0000269PubMed:15328353}.
Subcellular Localization Cell membrane {ECO:0000269PubMed:15328353}; Single-pass type II membrane protein {ECO:0000269PubMed:15328353}.Transmembrane protease serine 11E catalytic chain: Secreted. Note=Activated by cleavage and secreted.
Disease Associations
Tissue Specificity Expressed in epidermal, oral and male reproductive tissues. {ECO:0000269PubMed:15328353}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004252 serine-type endopeptidase activity
GO:0005515 protein binding
GO:0008236 serine-type peptidase activity
Biological Process
GO:0006508 proteolysis
GO:0050890 cognition
Cellular Component
GO:0005576 extracellular region
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
Protein Structure and Domains
PDB ID MGI:3513175
InterPro IPR000082 SEA domain
IPR001254 Peptidase S1
IPR001314 Peptidase S1A, chymotrypsin-type
IPR009003 Trypsin-like cysteine/serine peptidase domain
IPR017329 Peptidase S1A, HAT/DESC1
PFAM PF01390
PF00089
PRINTS PR00722
PIRSF PIRSF037941
SMART SM00200
SM00020
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q5S248
PhosphoSite PhosphoSite-Q5S248
TrEMBL
UniProt Splice Variant
Entrez Gene 243084
UniGene Mm.130801
RefSeq NP_766468
MGI ID
MGI Symbol Tmprss11e
OMIM
CCDS CCDS51533
HPRD
IMGT
EMBL AK037235 AY787860 BC115432 BC115433
GenPept AAI15433 AAI15434 AAV52922 BAC29770

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca