InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Mapk1

Summary

InnateDB Protein

IDBP-538727.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Mapk1

Protein Name

mitogen-activated protein kinase 1

Synonyms

9030612K14Rik; AA407128; AU018647; C78273; ERK; Erk2; MAPK2; p41mapk; p42mapk; Prkm1; PRKM2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000115125

InnateDB Gene

IDBG-137672 (Mapk1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 109 experimentally validated interaction(s) in this database.
They are also associated with 176 interaction(s) predicted by orthology.

Experimentally validated
Total	109 [view]
Protein-Protein	107 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	2 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	176 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001784	phosphotyrosine binding
GO:0004672	protein kinase activity
GO:0004707	MAP kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016301	kinase activity
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0000165	MAPK cascade
GO:0006468	protein phosphorylation
GO:0006974	cellular response to DNA damage stimulus
GO:0009887	organ morphogenesis
GO:0018105	peptidyl-serine phosphorylation
GO:0019858	cytosine metabolic process
GO:0031663	lipopolysaccharide-mediated signaling pathway
GO:0032496	response to lipopolysaccharide
GO:0033598	mammary gland epithelial cell proliferation
GO:0043330	response to exogenous dsRNA
GO:0045087	innate immune response (InnateDB)
GO:0045596	negative regulation of cell differentiation
GO:0050852	T cell receptor signaling pathway
GO:0050853	B cell receptor signaling pathway
GO:0060716	labyrinthine layer blood vessel development
GO:0097011	cellular response to granulocyte macrophage colony-stimulating factor stimulus

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005829	cytosol

Protein Structure and Domains

PDB ID

MGI:1346858

InterPro

IPR008349 Mitogen-activated protein (MAP) kinase, ERK1/2
IPR011009 Protein kinase-like domain

PFAM

PRINTS

PR01770

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

PhosphoSite-

TrEMBL

F6VEI7

UniProt Splice Variant

Entrez Gene

26413

UniGene

Mm.196581

RefSeq

MGI ID

MGI Symbol

Mapk1

OMIM

CCDS

HPRD

IMGT

EMBL

AC166346 AC166832

GenPept