InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ccpg1

Summary

InnateDB Protein

IDBP-539624.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ccpg1

Protein Name

cell cycle progression 1

Synonyms

1700030B06Rik; 1810073J13Rik; 9430028F23Rik; AI426686; AI875170; CPR8; D9Ertd392e;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000122966

InnateDB Gene

IDBG-184065 (Ccpg1)

Protein Structure

UniProt Annotation

Function

Acts as an assembly platform for Rho protein signaling complexes. Limits guanine nucleotide exchange activity of MCF2L toward RHOA, which results in an inhibition of both its transcriptional activation ability and its transforming activity. Does not inhibit activity of MCF2L toward CDC42, or activity of MCF2 toward either RHOA or CDC42. May be involved in cell cycle regulation. {ECO:0000269PubMed:17000758}.

Subcellular Localization

Cytoplasmic granule membrane {ECO:0000269PubMed:17000758}; Single-pass type II membrane protein {ECO:0000269PubMed:17000758}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0007049	cell cycle
GO:0008284	positive regulation of cell proliferation
GO:0045787	positive regulation of cell cycle
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:2001106	regulation of Rho guanyl-nucleotide exchange factor activity