InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Atp5j2

Summary

InnateDB Protein

IDBP-539642.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Atp5j2

Protein Name

ATP synthase, H+ transporting, mitochondrial F0 complex, subunit F2

Synonyms

1110019H14Rik;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000125504

InnateDB Gene

IDBG-208603 (Atp5j2)

Protein Structure

UniProt Annotation

Function

Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane.

Subcellular Localization

Mitochondrion. Mitochondrion inner membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 25 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	25 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0016887	ATPase activity

Biological Process

GO:0006200	ATP catabolic process
GO:0006754	ATP biosynthetic process
GO:0015992	proton transport

Cellular Component

GO:0005634	nucleus
GO:0005739	mitochondrion
GO:0005743	mitochondrial inner membrane
GO:0005753	mitochondrial proton-transporting ATP synthase complex
GO:0016021	integral component of membrane
GO:0045263	proton-transporting ATP synthase complex, coupling factor F(o)
GO:0070062	extracellular vesicular exosome