InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Zfr

Summary

InnateDB Protein

IDBP-539676.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Zfr

Protein Name

zinc finger RNA binding protein

Synonyms

C920030H05Rik;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000118911

InnateDB Gene

IDBG-129771 (Zfr)

Protein Structure

UniProt Annotation

Function

Involved in postimplantation and gastrulation stages of development. Binds to DNA and RNA. Involved in the nucleocytoplasmic shuttling of STAU2 (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus. Cytoplasm. Cytoplasmic granule {ECO:0000250}. Chromosome {ECO:0000250}. Note=Associated with chromosome foci in meiotic cells. Localizes in somatodendritic compartment of primary hippocampal neurons (By similarity). Colocalizes with STAU2 in several cytosolic RNA granules (By similarity). Associated with chromosomes. {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in Sertoli cells, spermatocytes, primary and growing oocytes and granulosa cells (at protein level). Expressed in testis, ovary and brain. {ECO:0000269PubMed:10072773, ECO:0000269PubMed:11283266}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 31 interaction(s) predicted by orthology.

Experimentally validated
Total	9 [view]
Protein-Protein	9 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	31 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0003677	DNA binding
GO:0003723	RNA binding
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0044822	poly(A) RNA binding