Mus musculus Protein: Kirrel | |||||||||||
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Summary | |||||||||||
InnateDB Protein | IDBP-539772.3 | ||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||
Gene Symbol | Kirrel | ||||||||||
Protein Name | kin of IRRE like (Drosophila) | ||||||||||
Synonyms | |||||||||||
Species | Mus musculus | ||||||||||
Ensembl Protein | ENSMUSP00000125525 | ||||||||||
InnateDB Gene | IDBG-156900 (Kirrel) | ||||||||||
Protein Structure | |||||||||||
UniProt Annotation | |||||||||||
Function | Plays a significant role in the normal development and function of the glomerular permeability. Is a signaling protein that needs the presence of TEC kinases to fully trans-activate the transcription factor AP-1. {ECO:0000269PubMed:11416156}. | ||||||||||
Subcellular Localization | Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Note=Predominantly located at podocyte slit diaphragm. | ||||||||||
Disease Associations | |||||||||||
Tissue Specificity | Abundantly expressed in kidney. Specifically expressed in podocytes of kidney glomeruli. {ECO:0000269PubMed:12865409}. | ||||||||||
Comments | |||||||||||
Interactions | |||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||||||||
PDB ID | MGI:1891396 | ||||||||||
InterPro |
IPR003598
Immunoglobulin subtype 2 IPR003599 Immunoglobulin subtype IPR007110 Immunoglobulin-like domain IPR013098 Immunoglobulin I-set IPR013106 Immunoglobulin V-set domain IPR013151 Immunoglobulin IPR013162 CD80-like, immunoglobulin C2-set |
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PFAM |
PF07679
PF07686 PF00047 PF08205 |
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PRINTS | |||||||||||
PIRSF | |||||||||||
SMART |
SM00408
SM00409 |
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TIGRFAMs | |||||||||||
Post-translational Modifications | |||||||||||
Modification | |||||||||||
Cross-References | |||||||||||
SwissProt | Q80W68 | ||||||||||
PhosphoSite | PhosphoSite-Q80W68 | ||||||||||
TrEMBL | |||||||||||
UniProt Splice Variant | |||||||||||
Entrez Gene | 170643 | ||||||||||
UniGene | Mm.89552 | ||||||||||
RefSeq | XP_006501139 | ||||||||||
MGI ID | 4OFD | ||||||||||
MGI Symbol | Kirrel | ||||||||||
OMIM | |||||||||||
CCDS | CCDS17450 | ||||||||||
HPRD | |||||||||||
IMGT | |||||||||||
EMBL | AF480411 AY017368 AY243095 BC023765 | ||||||||||
GenPept | AAH23765 AAK00528 AAN73043 AAO91769 | ||||||||||