InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Mlxipl

Summary

InnateDB Protein

IDBP-539776.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Mlxipl

Protein Name

MLX interacting protein-like

Synonyms

bHLHd14; ChREBP; Wbscr14; WS-bHLH;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000114933

InnateDB Gene

IDBG-203540 (Mlxipl)

Protein Structure

UniProt Annotation

Function

Transcriptional repressor. Binds to the canonical and non-canonical E box sequences 5'-CACGTG-3'.

Subcellular Localization

Nucleus {ECO:0000255PROSITE- ProRule:PRU00981}.

Disease Associations

Tissue Specificity

Expressed in the ventricular and intermediate zones of the developing spinal cord of E12.5 embryos. In later embryos expressed in a variety of tissues.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	8 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0035538	carbohydrate response element binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006351	transcription, DNA-templated
GO:0008284	positive regulation of cell proliferation
GO:0010255	glucose mediated signaling pathway
GO:0033137	negative regulation of peptidyl-serine phosphorylation
GO:0042593	glucose homeostasis
GO:0045723	positive regulation of fatty acid biosynthetic process
GO:0045821	positive regulation of glycolytic process
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0055089	fatty acid homeostasis
GO:0071157	negative regulation of cell cycle arrest
GO:0090324	negative regulation of oxidative phosphorylation
GO:2000505	regulation of energy homeostasis