InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Nox1

Summary

InnateDB Protein

IDBP-540178.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Nox1

Protein Name

NADPH oxidase 1

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000124355

InnateDB Gene

IDBG-170699 (Nox1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0016175	superoxide-generating NADPH oxidase activity
GO:0016491	oxidoreductase activity

Biological Process

GO:0003081	regulation of systemic arterial blood pressure by renin-angiotensin
GO:0030198	extracellular matrix organization
GO:0042554	superoxide anion generation
GO:0043410	positive regulation of MAPK cascade
GO:0045087	innate immune response (InnateDB)
GO:0046330	positive regulation of JNK cascade
GO:0055114	oxidation-reduction process
GO:0071455	cellular response to hyperoxia
GO:0072592	oxygen metabolic process
GO:1902177	positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway

Cellular Component

GO:0005737	cytoplasm
GO:0005768	endosome
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

MGI:2450016

InterPro

IPR000778 Cytochrome b245, heavy chain
IPR008333 Oxidoreductase, FAD-binding domain
IPR013112 FAD-binding 8
IPR013121 Ferric reductase, NAD binding
IPR013130 Ferric reductase transmembrane component-like domain
IPR017938 Riboflavin synthase-like beta-barrel

PFAM

PF00970
PF08022
PF08030
PF01794

PRINTS

PR00466

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite