Homo sapiens Protein: KLHL9
Summary
InnateDB Protein IDBP-54035.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol KLHL9
Protein Name kelch-like 9 (Drosophila)
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000351933
InnateDB Gene IDBG-54033 (KLHL9)
Protein Structure
UniProt Annotation
Function Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex mediates the ubiquitination of AURKB and controls the dynamic behavior of AURKB on mitotic chromosomes and thereby coordinates faithful mitotic progression and completion of cytokinesis. {ECO:0000269PubMed:14528312, ECO:0000269PubMed:17543862, ECO:0000269PubMed:19995937}.
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
Experimentally validated
Total 18 [view]
Protein-Protein 18 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
Biological Process
GO:0000910 cytokinesis
GO:0007067 mitotic nuclear division
GO:0016567 protein ubiquitination
Cellular Component
GO:0030496 midbody
GO:0031463 Cul3-RING ubiquitin ligase complex
Protein Structure and Domains
PDB ID
InterPro IPR000210 BTB/POZ-like
IPR006652 Kelch repeat type 1
IPR011333 BTB/POZ fold
IPR011498 Kelch repeat type 2
IPR011705 BTB/Kelch-associated
IPR013069 BTB/POZ
IPR017096 Kelch-like protein, gigaxonin type
PFAM PF01344
PF07646
PF07707
PF00651
PRINTS
PIRSF PIRSF037037
SMART SM00225
SM00612
SM00875
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9P2J3
PhosphoSite PhosphoSite-Q9P2J3
TrEMBL Q9H8J3
UniProt Splice Variant
Entrez Gene 55958
UniGene Hs.731843
RefSeq NP_061335
HUGO HGNC:18732
OMIM 611201
CCDS CCDS6503
HPRD 13929
IMGT
EMBL AB037775 AK023630 AK091715 AL162420 AL713669 BC039133 BC105008 BC113513 BX538121 CH471071
GenPept AAH39133 AAI05009 AAI13514 BAA92592 BAB14623 BAG52403 CAD28475 CAD98027 EAW58614