Version 5.4
Mus musculus Protein: Lpin2
Summary
InnateDB Protein IDBP-540501.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Lpin2
Protein Name lipin 2
Synonyms 2610511G02Rik; AI481352; AW742896;
Species Mus musculus
Ensembl Protein ENSMUSP00000120634
InnateDB Gene IDBG-196742 (Lpin2)
Protein Structure
UniProt Annotation
Function Plays important roles in controlling the metabolism of fatty acids at differents levels. Acts as a magnesium-dependent phosphatidate phosphatase enzyme which catalyzes the conversion of phosphatidic acid to diacylglycerol during triglyceride, phosphatidylcholine and phosphatidylethanolamine biosynthesis in the reticulum endoplasmic membrane. Acts also as a nuclear transcriptional coactivator for PPARGC1A to modulate lipid metabolism. {ECO:0000269PubMed:19136718, ECO:0000269PubMed:19717560}.
Subcellular Localization Nucleus. Cytoplasm, cytosol. Endoplasmic reticulum membrane. Note=Translocates from cytosol to endoplasmic reticulum membrane with increasing levels of oleate.
Disease Associations
Tissue Specificity Expressed at high level in liver and to some extend in lung, kidney, placenta, spleen, thymus, lymph node, prostate, testes, small intestine, and colon. Expressed also in circulating red blood cells and site of lymphopoiesis. {ECO:0000269PubMed:17158099, ECO:0000269PubMed:19717560}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003713 transcription coactivator activity
GO:0008195 phosphatidate phosphatase activity
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006629 lipid metabolic process
GO:0006631 fatty acid metabolic process
GO:0016311 dephosphorylation
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
Cellular Component
GO:0005634 nucleus
GO:0005789 endoplasmic reticulum membrane
GO:0005829 cytosol
Protein Structure and Domains
PDB ID MGI:1891341
InterPro IPR007651 Lipin, N-terminal
PFAM PF04571
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q99PI5
PhosphoSite PhosphoSite-Q99PI5
TrEMBL
UniProt Splice Variant
Entrez Gene 64898
UniGene Mm.446341
RefSeq
MGI ID
MGI Symbol Lpin2
OMIM
CCDS
HPRD
IMGT
EMBL AF286723 AK033662 AK050138 AK086834 BC039698
GenPept AAG52761 AAH39698 BAC28415 BAC34088 BAC39754

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca