InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Kit

Summary

InnateDB Protein

IDBP-541313.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Kit

Protein Name

kit oncogene

Synonyms

Bs; c-KIT; CD117; Fdc; Gsfsco1; Gsfsco5; Gsfsow3; SCO1; SCO5; SOW3; Ssm; Tr-kit; W;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000116465

InnateDB Gene

IDBG-172083 (Kit)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 35 experimentally validated interaction(s) in this database.
They are also associated with 43 interaction(s) predicted by orthology.

Experimentally validated
Total	35 [view]
Protein-Protein	35 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	43 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0004714	transmembrane receptor protein tyrosine kinase activity
GO:0004716	receptor signaling protein tyrosine kinase activity
GO:0005020	stem cell factor receptor activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0019955	cytokine binding

Biological Process

GO:0002318	myeloid progenitor cell differentiation
GO:0002320	lymphoid progenitor cell differentiation
GO:0002573	myeloid leukocyte differentiation
GO:0006468	protein phosphorylation
GO:0006687	glycosphingolipid metabolic process
GO:0006935	chemotaxis
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007281	germ cell development
GO:0007286	spermatid development
GO:0008284	positive regulation of cell proliferation
GO:0009314	response to radiation
GO:0010628	positive regulation of gene expression
GO:0018108	peptidyl-tyrosine phosphorylation
GO:0019221	cytokine-mediated signaling pathway
GO:0023014	signal transduction by phosphorylation
GO:0030097	hemopoiesis
GO:0030154	cell differentiation
GO:0035234	ectopic germ cell programmed cell death
GO:0035556	intracellular signal transduction
GO:0038093	Fc receptor signaling pathway
GO:0038109	Kit signaling pathway
GO:0043069	negative regulation of programmed cell death
GO:0043406	positive regulation of MAP kinase activity
GO:0043473	pigmentation
GO:0046777	protein autophosphorylation
GO:0048066	developmental pigmentation
GO:0048070	regulation of developmental pigmentation

Cellular Component

GO:0005911	cell-cell junction
GO:0009897	external side of plasma membrane
GO:0009986	cell surface
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

MGI:96677

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine- /dual specificity protein kinase, catalytic domain
IPR003598 Immunoglobulin subtype 2
IPR003599 Immunoglobulin subtype
IPR007110 Immunoglobulin-like domain
IPR011009 Protein kinase-like domain
IPR013098 Immunoglobulin I-set
IPR013151 Immunoglobulin
IPR016243 Tyrosine-protein kinase, CSF-1/PDGF receptor
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00069
PF07714
PF07679
PF00047

PRINTS

PR00109

PIRSF

PIRSF000615
PIRSF500947

SMART

SM00220
SM00408
SM00409
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

PhosphoSite-

TrEMBL

Q3ULJ6

UniProt Splice Variant

Entrez Gene

16590

UniGene

Mm.470465

RefSeq

MGI ID

MGI Symbol

Kit

OMIM

CCDS

HPRD

IMGT

EMBL

AC013622 AC115853 AK145462 GQ281541

GenPept

ACT22524 BAE26452