InnateDB Protein
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IDBP-541486.3
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Slc14a1
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Protein Name
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solute carrier family 14 (urea transporter), member 1
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Synonyms
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2610507K20Rik; 3021401A05Rik; UT-B; Utb1;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000125114
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InnateDB Gene
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IDBG-160561 (Slc14a1)
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Protein Structure
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Function |
Urea channel that facilitates transmembrane urea transport down a concentration gradient. A constriction of the transmembrane channel functions as selectivity filter through which urea is expected to pass in dehydrated form. The rate of urea conduction is increased by hypotonic stress. Plays an important role in the kidney medulla collecting ducts, where it allows rapid equilibration between the lumen of the collecting ducts and the interstitium, and thereby prevents water loss driven by the high concentration of urea in the urine. Facilitates urea transport across erythrocyte membranes. May also play a role in transmembrane water transport, possibly by indirect means. {ECO:0000269PubMed:11792714, ECO:0000269PubMed:12133842}.
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Subcellular Localization |
Cell membrane; Multi-pass membrane protein. Basolateral cell membrane; Multi-pass membrane protein. Note=Restricted to the basolateral membrane in various portions of the urothelium.
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Disease Associations |
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Tissue Specificity |
Expressed in brain, kidney, heart, liver, lung, skeletal muscle, spleen, testis, ureter and urinary bladder (at protein level). Along the gastrointestinal tract, detected in colon, jejunum and stomach (at protein level). In the kidney, expressed in some microvessels of the inner and outer medulla, but not all (at protein level). Not detected in the cortex (at protein level). Detected in the urothelium all along the urinary tract, including the papilla surface, the ureter, the bladder and the urethra (at protein level). In the brain, expressed at the border of the corpus callosum and striatum in astrocytic cellular processes surrounding blood microvessels (at protein level). Detected in erythrocytes (at protein level). {ECO:0000269PubMed:11792714, ECO:0000269PubMed:12133842, ECO:0000269PubMed:15563580}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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Molecular Function |
Accession |
GO Term |
GO:0005372
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water transmembrane transporter activity
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GO:0015204
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urea transmembrane transporter activity
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GO:0015265
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urea channel activity
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:1351654
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InterPro |
IPR004937
Urea transporter
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PFAM |
PF03253
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PRINTS |
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PIRSF |
PIRSF016502
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q8VHL0
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PhosphoSite |
PhosphoSite-Q8VHL0
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
108052
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UniGene |
Mm.403950
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RefSeq |
NP_001164481
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MGI ID |
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MGI Symbol |
Slc14a1
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OMIM |
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CCDS |
CCDS50330
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HPRD |
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IMGT |
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EMBL |
AF448798
AJ420967
AK012066
AK041979
AK153891
BC058594
BC086673
BC100570
CH466528
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GenPept |
AAH58594
AAH86673
AAI00571
AAL47138
BAB28004
BAC31119
BAE32238
CAD12807
EDL09437
EDL09438
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