InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Sox3

Summary

InnateDB Protein

IDBP-541545.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Sox3

Protein Name

SRY-box containing gene 3

Synonyms

Sox-3;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000115237

InnateDB Gene

IDBG-148746 (Sox3)

Protein Structure

UniProt Annotation

Function

Transcription factor required during the formation of the hypothalamo-pituitary axis. May function as a switch in neuronal development. Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation. Required also within the pharyngeal epithelia for craniofacial morphogenesis. Controls a genetic switch in male development. Is necessary for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells. {ECO:0000269PubMed:14981518, ECO:0000269PubMed:17728342, ECO:0000269PubMed:21183788}.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

Mainly in the developing central nervous system. Expressed in developing urogenital ridge.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000979	RNA polymerase II core promoter sequence-specific DNA binding
GO:0001106	RNA polymerase II transcription corepressor activity
GO:0003677	DNA binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006351	transcription, DNA-templated
GO:0007423	sensory organ development
GO:0007530	sex determination
GO:0009887	organ morphogenesis
GO:0021854	hypothalamus development
GO:0021983	pituitary gland development
GO:0030900	forebrain development
GO:0045665	negative regulation of neuron differentiation
GO:0048515	spermatid differentiation
GO:0060009	Sertoli cell development
GO:0060324	face development