Version 5.4
Mus musculus Protein: Gng2
Summary
InnateDB Protein IDBP-542282.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Gng2
Protein Name guanine nucleotide binding protein (G protein), gamma 2
Synonyms 82;
Species Mus musculus
Ensembl Protein ENSMUSP00000124725
InnateDB Gene IDBG-134150 (Gng2)
Protein Structure
UniProt Annotation
Function Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein- effector interaction.
Subcellular Localization Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}.
Disease Associations
Tissue Specificity Adrenal gland and brain.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 18 interaction(s) predicted by orthology.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 18 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003924 GTPase activity
GO:0004871 signal transducer activity
GO:0031681 G-protein beta-subunit binding
Biological Process
GO:0006184 GTP catabolic process
GO:0007186 G-protein coupled receptor signaling pathway
GO:0008283 cell proliferation
Cellular Component
GO:0005834 heterotrimeric G-protein complex
GO:0005886 plasma membrane
Protein Structure and Domains
PDB ID MGI:102705
InterPro IPR001770 G-protein, gamma subunit
IPR015898 G-protein gamma-like domain
PFAM PF00631
PRINTS PR00321
PIRSF
SMART SM00224
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P63213
PhosphoSite PhosphoSite-P63213
TrEMBL
UniProt Splice Variant
Entrez Gene 14702
UniGene Mm.452554
RefSeq
MGI ID
MGI Symbol Gng2
OMIM
CCDS CCDS26840
HPRD
IMGT
EMBL AF098488 AF098489 AK003588 AK012405 AK036138 AK075698 AK158697 AK160396 BC021599 U38496
GenPept AAB01727 AAD16272 AAH21599 BAB22878 BAB28219 BAC29316 BAC35896 BAE34615 BAE35765

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca