InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Sirt3

Summary

InnateDB Protein

IDBP-542565.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Sirt3

Protein Name

sirtuin 3 (silent mating type information regulation 2, homolog) 3 (S. cerevisiae)

Synonyms

2310003L23Rik; AI848213; Sir2l3;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000121151

InnateDB Gene

IDBG-211875 (Sirt3)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 95 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	95 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0032041	NAD-dependent histone deacetylase activity (H3-K14 specific)
GO:0070403	NAD+ binding

Biological Process

GO:0006476	protein deacetylation
GO:0009060	aerobic respiration
GO:0034983	peptidyl-lysine deacetylation
GO:0070932	histone H3 deacetylation

Cellular Component

GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005759	mitochondrial matrix
GO:0016020	membrane

Protein Structure and Domains

PDB ID

MGI:1927665

InterPro

IPR003000 Sirtuin family
IPR026590 Sirtuin family, catalytic core domain
IPR029035 DHS-like NAD/FAD-binding domain

PFAM

PF02146

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

PhosphoSite-

TrEMBL

D3YWD6

UniProt Splice Variant

Entrez Gene

64384

UniGene

RefSeq

MGI ID

MGI Symbol

Sirt3

OMIM

CCDS

HPRD

IMGT

EMBL

AC107815 AF299338 AF299339 AF302274 AF302275 AF302276 AF302277 AF302278 AK075861 BC025878 EU886466 FJ621493

GenPept

AAG33227 AAG39257 AAG39258 AAH25878 ACJ70655 ACM68947 BAC36012