InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Sirt3

Summary

InnateDB Protein

IDBP-542568.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Sirt3

Protein Name

sirtuin 3 (silent mating type information regulation 2, homolog) 3 (S. cerevisiae)

Synonyms

2310003L23Rik; AI848213; Sir2l3;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000114247

InnateDB Gene

IDBG-211875 (Sirt3)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 95 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	95 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008270	zinc ion binding
GO:0032041	NAD-dependent histone deacetylase activity (H3-K14 specific)
GO:0070403	NAD+ binding

Biological Process

GO:0006476	protein deacetylation
GO:0009060	aerobic respiration
GO:0034983	peptidyl-lysine deacetylation
GO:0070932	histone H3 deacetylation

Cellular Component

GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0016020	membrane

Protein Structure and Domains

PDB ID

MGI:1927665

InterPro

IPR003000 Sirtuin family
IPR026590 Sirtuin family, catalytic core domain
IPR029035 DHS-like NAD/FAD-binding domain

PFAM

PF02146

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

PhosphoSite-

TrEMBL

D3YWD6

UniProt Splice Variant

Entrez Gene

64384

UniGene

RefSeq

XP_006536285

MGI ID

MGI Symbol

Sirt3

OMIM

CCDS

HPRD

IMGT

EMBL

AC107815

GenPept