InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Mkl1

Summary

InnateDB Protein

IDBP-542596.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Mkl1

Protein Name

MKL (megakaryoblastic leukemia)/myocardin-like 1

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000119530

InnateDB Gene

IDBG-164431 (Mkl1)

Protein Structure

UniProt Annotation

Function

Transcriptional coactivator of serum response factor (SRF) with the potential to modulate SRF target genes. Suppresses TNF-induced cell death by inhibiting activation of caspases; its transcriptional activity is indispensable for the antiapoptotic function. It may up-regulate antiapoptotic molecules, which in turn inhibit caspase activation. {ECO:0000269PubMed:19350017}.

Subcellular Localization

Cytoplasm. Nucleus. Note=Binding to globular actin is required to maintain cytoplasmic localization. Nuclear localization is regulated by MICAL2, which mediates depolymerization of nuclear globular actin, promoting retention of MKL1 in the nucleus and subsequent formation of an active complex with SRF (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in heart, brain, spleen, lung, liver, muscle, kidney and testis.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 17 interaction(s) predicted by orthology.

Experimentally validated
Total	9 [view]
Protein-Protein	9 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	17 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000976	transcription regulatory region sequence-specific DNA binding
GO:0003676	nucleic acid binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003713	transcription coactivator activity
GO:0003779	actin binding
GO:0003785	actin monomer binding
GO:0005515	protein binding
GO:0043522	leucine zipper domain binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0010735	positive regulation of transcription via serum response element binding
GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0051145	smooth muscle cell differentiation
GO:2001234	negative regulation of apoptotic signaling pathway