InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: IFNA1

Summary

InnateDB Protein

IDBP-54278.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

IFNA1

Protein Name

interferon, alpha 1

Synonyms

IFL; IFN; IFN-ALPHA; IFN-alphaD; IFNA@; IFNA13;

Species

Homo sapiens

Ensembl Protein

ENSP00000276927

InnateDB Gene

IDBG-54276 (IFNA1)

Protein Structure

UniProt Annotation

Function

Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase. {ECO:0000269PubMed:1634550}.

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.

Experimentally validated
Total	13 [view]
Protein-Protein	3 [view]
Protein-DNA	10 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005125	cytokine activity
GO:0005126	cytokine receptor binding
GO:0005132	type I interferon receptor binding

Biological Process

GO:0002250	adaptive immune response
GO:0002286	T cell activation involved in immune response
GO:0002323	natural killer cell activation involved in immune response
GO:0006952	defense response
GO:0006959	humoral immune response
GO:0007596	blood coagulation
GO:0019221	cytokine-mediated signaling pathway
GO:0030183	B cell differentiation
GO:0033141	positive regulation of peptidyl-serine phosphorylation of STAT protein
GO:0042100	B cell proliferation
GO:0043330	response to exogenous dsRNA
GO:0045087	innate immune response (InnateDB)
GO:0045343	regulation of MHC class I biosynthetic process
GO:0051607	defense response to virus
GO:0060337	type I interferon signaling pathway
GO:0060338	regulation of type I interferon-mediated signaling pathway