Version 5.4
Homo sapiens Protein: ZXDC
Summary
InnateDB Protein IDBP-54602.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ZXDC
Protein Name ZXD family zinc finger C
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000374359
InnateDB Gene IDBG-54598 (ZXDC)
Protein Structure
UniProt Annotation
Function Cooperates with CIITA to promote transcription of MHC class I and MHC class II genes. {ECO:0000269PubMed:16600381, ECO:0000269PubMed:17493635, ECO:0000269PubMed:17696781}.
Subcellular Localization Nucleus {ECO:0000305}.
Disease Associations
Tissue Specificity Expressed at high levels in heart, kidney, liver and testis, at moderate levels in brain and stomach, and at low levels in lung, muscle, placenta, small intestine and spleen. {ECO:0000269PubMed:16600381}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
Experimentally validated
Total 15 [view]
Protein-Protein 15 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003676 nucleic acid binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0030275 LRR domain binding
GO:0046872 metal ion binding
GO:0070742 C2H2 zinc finger domain binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
Cellular Component
GO:0005575 cellular_component
GO:0005634 nucleus
Protein Structure and Domains
PDB ID
InterPro IPR007087 Zinc finger, C2H2
IPR015880 Zinc finger, C2H2-like
PFAM PF00096
PRINTS
PIRSF
SMART SM00355
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q2QGD7
PhosphoSite PhosphoSite-Q2QGD7
TrEMBL Q9H891
UniProt Splice Variant
Entrez Gene 79364
UniGene Hs.440049
RefSeq NP_079388
HUGO HGNC:28160
OMIM 615746
CCDS CCDS43145
HPRD 14420
IMGT
EMBL AC024558 AC073439 AK023923 AK092101 AL390142 AY936556 BC002940 BC012729 BC073859 DQ079590 FJ980275
GenPept AAH02940 AAH12729 AAH73859 AAX23974 AAZ30918 ACR56328 BAB14726 BAC03805 CAH10665

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca