InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CKAP4

Summary

InnateDB Protein

IDBP-54748.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CKAP4

Protein Name

cytoskeleton-associated protein 4

Synonyms

CLIMP-63; ERGIC-63; p63;

Species

Homo sapiens

Ensembl Protein

ENSP00000367265

InnateDB Gene

IDBG-54744 (CKAP4)

Protein Structure

UniProt Annotation

Function

High-affinity epithelial cell surface receptor for APF.Mediates the anchoring of the endoplasmic reticulum to microtubules.

Subcellular Localization

Endoplasmic reticulum membrane; Single-pass type II membrane protein. Cell membrane; Single-pass type II membrane protein. Cytoplasm, cytoskeleton. Cytoplasm, perinuclear region. Note=Translocates to the perinuclear region upon APF- stimulation.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 33 experimentally validated interaction(s) in this database.

Experimentally validated
Total	33 [view]
Protein-Protein	33 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0004871	signal transducer activity
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006355	regulation of transcription, DNA-templated
GO:0007165	signal transduction
GO:0032784	regulation of DNA-templated transcription, elongation

Cellular Component

GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0005811	lipid particle
GO:0005856	cytoskeleton
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0048471	perinuclear region of cytoplasm
GO:0070062	extracellular vesicular exosome