InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: GEMIN5

Summary

InnateDB Protein

IDBP-55080.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GEMIN5

Protein Name

gem (nuclear organelle) associated protein 5

Synonyms

GEMIN-5;

Species

Homo sapiens

Ensembl Protein

ENSP00000285873

InnateDB Gene

IDBG-55078 (GEMIN5)

Protein Structure

UniProt Annotation

Function

The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus. GEMIN5 acts as the snRNA-binding protein of the SMN complex. {ECO:0000269PubMed:11714716, ECO:0000269PubMed:16857593, ECO:0000269PubMed:18984161}.

Subcellular Localization

Nucleus, nucleoplasm {ECO:0000269PubMed:11714716}. Nucleus, gem {ECO:0000269PubMed:11714716}. Cytoplasm {ECO:0000269PubMed:11714716}. Note=Found both in the nucleoplasm and in nuclear bodies called gems (Gemini of Cajal bodies) that are often in proximity to Cajal (coiled) bodies. Also found in the cytoplasm.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 48 experimentally validated interaction(s) in this database.

Experimentally validated
Total	48 [view]
Protein-Protein	48 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0017069	snRNA binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0000387	spliceosomal snRNP assembly
GO:0000398	mRNA splicing, via spliceosome
GO:0006461	protein complex assembly
GO:0010467	gene expression
GO:0016070	RNA metabolic process
GO:0034660	ncRNA metabolic process

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0016020	membrane
GO:0016604	nuclear body
GO:0032797	SMN complex
GO:0034719	SMN-Sm protein complex
GO:0097504	Gemini of coiled bodies