InnateDB Protein
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IDBP-55444.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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PLAUR
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Protein Name
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plasminogen activator, urokinase receptor
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Synonyms
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CD87; U-PAR; UPAR; URKR;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000342049
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InnateDB Gene
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IDBG-55442 (PLAUR)
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Protein Structure
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Function |
Acts as a receptor for urokinase plasminogen activator. Plays a role in localizing and promoting plasmin formation. Mediates the proteolysis-independent signal transduction activation effects of U-PA. It is subject to negative-feedback regulation by U-PA which cleaves it into an inactive form.
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Subcellular Localization |
Isoform 1: Cell membrane; Lipid-anchor, GPI- anchor.Isoform 2: Secreted {ECO:0000305}.
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Disease Associations |
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Tissue Specificity |
Expressed in neurons of the rolandic area of the brain (at protein level). Expressed in the brain.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 41 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
41
[view]
|
Protein-Protein |
37
[view]
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Protein-DNA |
4
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR001526
CD59 antigen
IPR016054
Ly-6 antigen / uPA receptor -like
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PFAM |
PF00021
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PRINTS |
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PIRSF |
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SMART |
SM00134
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TIGRFAMs |
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Modification |
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SwissProt |
Q03405
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PhosphoSite |
PhosphoSite-Q03405
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TrEMBL |
Q9UPI5
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UniProt Splice Variant |
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Entrez Gene |
5329
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UniGene |
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RefSeq |
NP_001005376
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HUGO |
HGNC:9053
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OMIM |
173391
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CCDS |
CCDS33041
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HPRD |
01421
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IMGT |
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EMBL |
AC005525
AC006953
AF257789
AK290774
AY029180
AY194849
AY620435
AY620436
AY620437
BC002788
CH471126
CR456952
M83246
S78532
U08839
U09346
U09347
U09931
U09932
U09933
U09935
U09936
U09937
X51675
X74039
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GenPept |
AAA17978
AAA17979
AAA59862
AAB60333
AAB60690
AAC32739
AAD14289
AAD17387
AAD17388
AAD17389
AAF71751
AAH02788
AAK31795
AAN86351
AAT52166
AAT52167
AAT52168
BAF83463
CAA35981
CAA52191
CAG33233
EAW57220
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