InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PCSK2

Summary

InnateDB Protein

IDBP-55844.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PCSK2

Protein Name

proprotein convertase subtilisin/kexin type 2

Synonyms

NEC 2; NEC-2; NEC2; PC2; SPC2;

Species

Homo sapiens

Ensembl Protein

ENSP00000262545

InnateDB Gene

IDBG-55840 (PCSK2)

Protein Structure

UniProt Annotation

Function

Involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. Responsible for the release of glucagon from proglucagon in pancreatic A cells. {ECO:0000269PubMed:9287128}.

Subcellular Localization

Cytoplasmic vesicle, secretory vesicle. Note=Localized in the secretion granules.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004175	endopeptidase activity
GO:0004252	serine-type endopeptidase activity
GO:0005515	protein binding
GO:0032403	protein complex binding

Biological Process

GO:0006508	proteolysis
GO:0007399	nervous system development
GO:0016485	protein processing
GO:0016486	peptide hormone processing
GO:0016540	protein autoprocessing
GO:0030070	insulin processing
GO:0034230	enkephalin processing
GO:0034231	islet amyloid polypeptide processing
GO:0044267	cellular protein metabolic process

Cellular Component

GO:0005615	extracellular space
GO:0016020	membrane
GO:0030133	transport vesicle
GO:0030141	secretory granule
GO:0030425	dendrite
GO:0034774	secretory granule lumen
GO:0043025	neuronal cell body
GO:0043204	perikaryon

Protein Structure and Domains

PDB ID

InterPro

IPR000209 Peptidase S8/S53 domain
IPR002884 Proprotein convertase, P
IPR008979 Galactose-binding domain-like
IPR009020 Proteinase inhibitor, propeptide
IPR015500 Peptidase S8, subtilisin-related

PFAM

PF00082
PF01483

PRINTS

PR00723

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P16519