InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: DDX58

Summary

InnateDB Protein

IDBP-55860.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DDX58

Protein Name

DEAD (Asp-Glu-Ala-Asp) box polypeptide 58

Synonyms

RIG-I; RIGI; RLR-1;

Species

Homo sapiens

Ensembl Protein

ENSP00000369197

InnateDB Gene

IDBG-55854 (DDX58)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 119 experimentally validated interaction(s) in this database.
They are also associated with 19 interaction(s) predicted by orthology.

Experimentally validated
Total	119 [view]
Protein-Protein	108 [view]
Protein-DNA	7 [view]
Protein-RNA	2 [view]
DNA-DNA	0
RNA-RNA	1 [view]
DNA-RNA	1 [view]

Predicted by orthology
Total	19 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0003677	DNA binding
GO:0004386	helicase activity
GO:0005524	ATP binding
GO:0016787	hydrolase activity
GO:0016817	hydrolase activity, acting on acid anhydrides

Biological Process

GO:0008152	metabolic process
GO:0045087	innate immune response (InnateDB)

Cellular Component

GO:0005737

cytoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR001650 Helicase, C-terminal
IPR006935 Helicase/UvrB domain
IPR011545 DEAD/DEAH box helicase domain
IPR014001 Helicase, superfamily 1/2, ATP-binding domain
IPR021673 C-terminal domain of RIG-I
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00271
PF04851
PF00270
PF11648

PRINTS

PIRSF

SMART

SM00490
SM00487

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite