Version 5.4
Homo sapiens Protein: CDNF
Summary
InnateDB Protein IDBP-55914.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CDNF
Protein Name cerebral dopamine neurotrophic factor
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000367703
InnateDB Gene IDBG-55912 (CDNF)
Protein Structure
UniProt Annotation
Function Trophic factor for dopamine neurons. Prevents the 6- hydroxydopamine (6-OHDA)-induced degeneration of dopaminergic neurons. When administered after 6-OHDA-lesioning, restores the dopaminergic function and prevents the degeneration of dopaminergic neurons in substantia nigra (By similarity). {ECO:0000250}.
Subcellular Localization Secreted {ECO:0000269PubMed:17611540, ECO:0000269PubMed:18561914}.
Disease Associations
Tissue Specificity Widely expressed in neuronal and non-neuronal tissues. In the brain, highest levels in the optic nerve and corpus callosum. {ECO:0000269PubMed:17611540}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0008083 growth factor activity
Biological Process
Cellular Component
GO:0005576 extracellular region
Protein Structure and Domains
PDB ID
InterPro IPR019345 Armet protein
PFAM PF10208
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q49AH0
PhosphoSite PhosphoSite-Q49AH0
TrEMBL
UniProt Splice Variant
Entrez Gene 441549
UniGene Hs.559067
RefSeq
HUGO HGNC:24913
OMIM 611233
CCDS
HPRD
IMGT
EMBL AK301259 BC037872 BC133042 BC133044 CH471072
GenPept AAH37872 AAI33043 AAI33045 BAG62825 EAW86264

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

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Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca