Version 5.4
Homo sapiens Protein: KCTD10
Summary
InnateDB Protein IDBP-56080.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol KCTD10
Protein Name potassium channel tetramerisation domain containing 10
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000228495
InnateDB Gene IDBG-56078 (KCTD10)
Protein Structure
UniProt Annotation
Function Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex. The BCR(BACURD3) E3 ubiquitin ligase complex mediates the ubiquitination of target proteins, leading to their degradation by the proteasome (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000269PubMed:19125419}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.
Experimentally validated
Total 20 [view]
Protein-Protein 19 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
Biological Process
GO:0016567 protein ubiquitination
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0051260 protein homooligomerization
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0031463 Cul3-RING ubiquitin ligase complex
GO:0036038 TCTN-B9D complex
Protein Structure and Domains
PDB ID
InterPro IPR000210 BTB/POZ-like
IPR003131 Potassium channel tetramerisation-type BTB domain
IPR011333 BTB/POZ fold
IPR013069 BTB/POZ
PFAM PF02214
PF00651
PRINTS
PIRSF
SMART SM00225
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9H3F6
PhosphoSite PhosphoSite-Q9H3F6
TrEMBL F5H268
UniProt Splice Variant
Entrez Gene 83892
UniGene Hs.609614
RefSeq NP_114160
HUGO HGNC:23236
OMIM 613421
CCDS CCDS9128
HPRD 13762
IMGT
EMBL AB209358 AC007570 AF113208 AK027543 AK123733 AK222548 AY205299 AY597809 BC040062 CH471054
GenPept AAG39279 AAH40062 AAO47716 AAT09002 BAB55188 BAD92595 BAD96268 BAG53947 EAW97860 EAW97861 EAW97862

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca