Version 5.4
Homo sapiens Protein: COL6A5
Summary
InnateDB Protein IDBP-56305.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol COL6A5
Protein Name collagen, type VI, alpha 5
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000309762
InnateDB Gene IDBG-56303 (COL6A5)
Protein Structure
UniProt Annotation
Function Collagen VI acts as a cell-binding protein. {ECO:0000250}.
Subcellular Localization Secreted, extracellular space, extracellular matrix {ECO:0000250}. Note=Deposed in the extracellular matrix of skeletal muscle. {ECO:0000250}.
Disease Associations Note=Patients affected by atopic dermatitis display an abnormal distribution of COL29A1 mRNA and protein in skin suggesting that COL29A1 may be involved in the pathogenesis of the disease.
Tissue Specificity Expressed in skin, followed by lung, small intestine, colon and testis. In skin, it is expressed in the epidermis with strongest staining in suprabasal viable layers. In ATOD patients, it is absent in the most differentiated upper spinous and granular layers (at protein level). {ECO:0000269PubMed:17850181}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0007155 cell adhesion
GO:0022617 extracellular matrix disassembly
GO:0030198 extracellular matrix organization
GO:0030574 collagen catabolic process
Cellular Component
GO:0005576 extracellular region
GO:0005578 proteinaceous extracellular matrix
GO:0005581 collagen trimer
GO:0031012 extracellular matrix
Protein Structure and Domains
PDB ID
InterPro IPR002035 von Willebrand factor, type A
IPR008160 Collagen triple helix repeat
PFAM PF00092
PF01391
PRINTS
PIRSF
SMART SM00327
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt A8TX70
PhosphoSite PhosphoSite-A8TX70
TrEMBL
UniProt Splice Variant
Entrez Gene 256076
UniGene Hs.205403
RefSeq
HUGO HGNC:26674
OMIM 611916
CCDS
HPRD 08196
IMGT
EMBL AC093004 AC117398 AK093199 AK123718 AM906078 AM906079 AM906080 AM906081 AM906082 AM906083 AM906084 EU085556
GenPept ABW81241 BAC04092 BAC85681 CAP19997 CAP19998 CAP19999 CAP20000 CAP20001 CAP20002 CAP20003

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca