Version 5.4
Homo sapiens Protein: TXNL4A
Summary
InnateDB Protein IDBP-5633.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TXNL4A
Protein Name thioredoxin-like 4A
Synonyms DIB1; DIM1; HsT161; SNRNP15; TXNL4; U5-15kD;
Species Homo sapiens
Ensembl Protein ENSP00000269601
InnateDB Gene IDBG-5631 (TXNL4A)
Protein Structure
UniProt Annotation
Function Essential role in pre-mRNA splicing as component of the U5 snRNP and U4/U6-U5 tri-snRNP complexes that are involved in spliceosome assembly. {ECO:0000269PubMed:10610776}.
Subcellular Localization Nucleus {ECO:0000269PubMed:20858735}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
Experimentally validated
Total 12 [view]
Protein-Protein 12 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0000245 spliceosomal complex assembly
GO:0000375 RNA splicing, via transesterification reactions
GO:0000398 mRNA splicing, via spliceosome
GO:0007067 mitotic nuclear division
GO:0008380 RNA splicing
GO:0010467 gene expression
GO:0045454 cell redox homeostasis
Cellular Component
GO:0005654 nucleoplasm
GO:0005681 spliceosomal complex
Protein Structure and Domains
PDB ID
InterPro IPR004123 mRNA splicing factor, thioredoxin-like U5 snRNP
IPR012336 Thioredoxin-like fold
IPR013766 Thioredoxin domain
PFAM PF02966
PF13098
PF13192
PF13462
PF13905
PF00085
PRINTS
PIRSF PIRSF017199
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P83876
PhosphoSite PhosphoSite-P83876
TrEMBL K7ESL1
UniProt Splice Variant
Entrez Gene 10907
UniGene
RefSeq NP_006692
HUGO HGNC:30551
OMIM 611595
CCDS CCDS32852
HPRD 18252
IMGT
EMBL AC090360 AF023611 AF146373 AK314901 BC001046 BC019272 CH471117
GenPept AAB81950 AAF17332 AAH01046 AAH19272 BAG37415 EAW66640

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca