InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: DNAJA1

Summary

InnateDB Protein

IDBP-56415.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DNAJA1

Protein Name

DnaJ (Hsp40) homolog, subfamily A, member 1

Synonyms

DJ-2; DjA1; hDJ-2; HDJ2; HSDJ; HSJ2; HSPF4; NEDD7;

Species

Homo sapiens

Ensembl Protein

ENSP00000369127

InnateDB Gene

IDBG-56413 (DNAJA1)

Protein Structure

UniProt Annotation

Function

Co-chaperone for HSPA8/Hsc70 (PubMed:10816573). Stimulates ATP hydrolysis, but not the folding of unfolded proteins mediated by HSPA1A (in vitro) (PubMed:24318877). Plays a role in protein transport into mitochondria via its role as co- chaperone. Functions as co-chaperone for HSPA1B and negatively regulates the translocation of BAX from the cytosol to mitochondria in response to cellular stress, thereby protecting cells against apoptosis (PubMed:14752510). Promotes apoptosis in response to cellular stress mediated by exposure to anisomycin or UV (PubMed:24512202). {ECO:0000269PubMed:10816573, ECO:0000269PubMed:14752510, ECO:0000269PubMed:24318877, ECO:0000269PubMed:24512202, ECO:0000269PubMed:9192730}.

Subcellular Localization

Membrane {ECO:0000305PubMed:10816573}; Lipid-anchor {ECO:0000305PubMed:10816573}. Cytoplasm {ECO:0000269PubMed:10816573}. Microsome {ECO:0000250}. Nucleus {ECO:0000269PubMed:10816573}. Cytoplasm, perinuclear region {ECO:0000269PubMed:10816573}. Mitochondrion {ECO:0000250}. Note=Primarily associated with microsomes. A minor proportion is associated with mitochondria (By similarity). Primarily cytoplasmic. A minor proportion is associated with nuclei. {ECO:0000250}.

Disease Associations

Tissue Specificity

Ubiquitous. Isoform 2 is highly expressed in testis and lung, but detected at low levels in thymus, prostate, colon and liver. {ECO:0000269PubMed:10816573, ECO:0000269PubMed:15595953}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 113 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	113 [view]
Protein-Protein	113 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0030544	Hsp70 protein binding
GO:0031072	heat shock protein binding
GO:0046872	metal ion binding
GO:0050750	low-density lipoprotein particle receptor binding
GO:0051082	unfolded protein binding
GO:0051087	chaperone binding

Biological Process

GO:0006457	protein folding
GO:0006986	response to unfolded protein
GO:0007283	spermatogenesis
GO:0009408	response to heat
GO:0030317	sperm motility
GO:0030521	androgen receptor signaling pathway
GO:0042769	DNA damage response, detection of DNA damage
GO:0043065	positive regulation of apoptotic process
GO:0043066	negative regulation of apoptotic process
GO:0043508	negative regulation of JUN kinase activity
GO:0051223	regulation of protein transport
GO:0070585	protein localization to mitochondrion

Cellular Component

GO:0005829	cytosol
GO:0016020	membrane
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR001305 Heat shock protein DnaJ, cysteine-rich domain
IPR001623 DnaJ domain
IPR002939 Chaperone DnaJ, C-terminal
IPR008971 HSP40/DnaJ peptide-binding

PFAM

PF00684
PF00226
PF01556

PRINTS

PR00625

PIRSF

SMART

SM00271

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt