Version 5.4
Homo sapiens Protein: TSPAN7
Summary
InnateDB Protein IDBP-56429.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TSPAN7
Protein Name tetraspanin 7
Synonyms A15; CCG-B7; CD231; DXS1692E; MRX58; MXS1; TALLA-1; TM4SF2; TM4SF2b;
Species Homo sapiens
Ensembl Protein ENSP00000367743
InnateDB Gene IDBG-56427 (TSPAN7)
Protein Structure
UniProt Annotation
Function May be involved in cell proliferation and cell motility.
Subcellular Localization Membrane; Multi-pass membrane protein.
Disease Associations Mental retardation, X-linked 58 (MRX58) [MIM:300210]: A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. Intellectual deficiency is the only primary symptom of non- syndromic X-linked mental retardation, while syndromic mental retardation presents with associated physical, neurological and/or psychiatric manifestations. {ECO:0000269PubMed:10655063}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Tissue Specificity Not solely expressed in T-cells. Expressed in acute myelocytic leukemia cells of some patients.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0016032 viral process
Cellular Component
GO:0005887 integral component of plasma membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR000301 Tetraspanin
IPR008952 Tetraspanin, EC2 domain
IPR018499 Tetraspanin/Peripherin
PFAM PF00335
PRINTS PR00259
PIRSF PIRSF002419
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P41732
PhosphoSite PhosphoSite-P41732
TrEMBL Q7Z3Z6
UniProt Splice Variant
Entrez Gene 7102
UniGene Hs.441664
RefSeq NP_004606
HUGO HGNC:11854
OMIM 300096
CCDS CCDS14248
HPRD 02107
IMGT
EMBL AB062057 AB102401 AB102402 AB102403 AB102404 AB102405 AB102406 AB102407 AB102408 AB102409 AB102410 AB102411 AB102412 AB102413 AB102414 AB102415 AB102416 AB102417 AB102418 AB102419 AB102420 AB102461 AB102462 AB102463 AB102464 AB102465 AB102466 AB102467 AB102468 AB102469 AB102470 AB102471 AB102472 AB102473 AB102474 AB102475 AB102476 AB102477 AB102478 AB102479 AB102480 AB102491 AB102492 AB102493 AB102494 AB102495 AB102496 AB102497 AB102498 AB102499 AB102500 AB102501 AB102502 AB102503 AB102504 AB102505 AB102506 AB102507 AB102508 AB102509 AB102510 AB102521 AB102522 AB102523 AB102524 AB102525 AB102526 AB102527 AB102528 AB102529 AB102530 AB102531 AB102532 AB102533 AB102534 AB102535 AB102536 AB102537 AB102538 AB102539 AB102540 AB102665 AJ250562 AJ250563 AJ250564 AJ250565 AJ250566 AJ250567 AJ250568 AK312343 BC018036 CH471141 D10653 D29808
GenPept AAH18036 BAA01501 BAA06191 BAB55824 BAB55825 BAC80900 BAC80901 BAC80902 BAC80903 BAC80904 BAC80905 BAC80906 BAC80907 BAC80908 BAC80909 BAC80910 BAC80911 BAC80912 BAC80913 BAC80914 BAC80915 BAC80916 BAC80917 BAC80918 BAC80919 BAC80930 BAC80931 BAC80932 BAC80933 BAC80934 BAC80935 BAC80936 BAC80937 BAC80938 BAC80939 BAC80940 BAC80941 BAC80942 BAC80943 BAC80944 BAC80945 BAC80946 BAC80947 BAC80948 BAC80949 BAC80960 BAC80961 BAC80962 BAC80963 BAC80964 BAC80965 BAC80966 BAC80967 BAC80968 BAC80969 BAC80970 BAC80971 BAC80972 BAC80973 BAC80974 BAC80975 BAC80976 BAC80977 BAC80978 BAC80979 BAC80990 BAC80991 BAC80992 BAC80993 BAC80994 BAC80995 BAC80996 BAC80997 BAC80998 BAC80999 BAC81000 BAC81001 BAC81002 BAC81003 BAC81004 BAC81005 BAC81006 BAC81007 BAC81008 BAC81009 BAC81134 BAG35264 CAB65594 EAW59437 EAW59438

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

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Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca