InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PNPO

Summary

InnateDB Protein

IDBP-56441.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PNPO

Protein Name

pyridoxamine 5'-phosphate oxidase

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000225573

InnateDB Gene

IDBG-56439 (PNPO)

Protein Structure

UniProt Annotation

Function

Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP). {ECO:0000269PubMed:12824491}.

Subcellular Localization

Disease Associations

Pyridoxine-5'-phosphate oxidase deficiency (PNPO deficiency) [MIM:610090]: The main feature of neonatal epileptic encephalopathy is the onset within hours of birth of a severe seizure disorder that does not respond to anticonvulsant drugs and can be fatal. Seizures can cease with the administration of PLP, being resistant to treatment with pyridoxine,. {ECO:0000269PubMed:15772097}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.

Experimentally validated
Total	4 [view]
Protein-Protein	3 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004733	pyridoxamine-phosphate oxidase activity
GO:0010181	FMN binding
GO:0016491	oxidoreductase activity
GO:0016638	oxidoreductase activity, acting on the CH-NH2 group of donors

Biological Process

GO:0006766	vitamin metabolic process
GO:0006767	water-soluble vitamin metabolic process
GO:0008615	pyridoxine biosynthetic process
GO:0042816	vitamin B6 metabolic process
GO:0042823	pyridoxal phosphate biosynthetic process
GO:0044281	small molecule metabolic process
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005829	cytosol
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR000659 Pyridoxamine 5\'-phosphate oxidase
IPR011576 Pyridoxamine 5\'-phosphate oxidase-like, FMN-binding domain
IPR012349 FMN-binding split barrel
IPR019576 Pyridoxine 5\'-phosphate oxidase, dimerisation, C-terminal

PFAM

PF01243
PF10590

PRINTS

PIRSF

PIRSF000190

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9NVS9