Version 5.4
Homo sapiens Protein: NUDCD2
Summary
InnateDB Protein IDBP-56564.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NUDCD2
Protein Name NudC domain containing 2
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000304854
InnateDB Gene IDBG-56560 (NUDCD2)
Protein Structure
UniProt Annotation
Function May regulate the LIS1/dynein pathway by stabilizing LIS1 with Hsp90 chaperone. {ECO:0000269PubMed:20133715}.
Subcellular Localization Chromosome, centromere, kinetochore {ECO:0000269PubMed:20133715}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269PubMed:20133715}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269PubMed:20133715}. Note=Associates with centrosomes in interphase and to spindle poles and kinetochores during mitosis.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 62 experimentally validated interaction(s) in this database.
Experimentally validated
Total 62 [view]
Protein-Protein 62 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
Cellular Component
GO:0000777 condensed chromosome kinetochore
GO:0000922 spindle pole
GO:0005622 intracellular
GO:0005737 cytoplasm
GO:0005815 microtubule organizing center
GO:0015630 microtubule cytoskeleton
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR007052 CS domain
IPR008978 HSP20-like chaperone
PFAM PF04969
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8WVJ2
PhosphoSite PhosphoSite-Q8WVJ2
TrEMBL
UniProt Splice Variant
Entrez Gene 134492
UniGene
RefSeq NP_660309
HUGO HGNC:30535
OMIM
CCDS CCDS4361
HPRD 14058
IMGT
EMBL AK311957 BC017934 BX538290 CH471062 FJ215684
GenPept AAH17934 ACJ05660 BAG34897 CAD98085 EAW61527

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca