InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: WWC1

Summary

InnateDB Protein

IDBP-56835.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

WWC1

Protein Name

WW and C2 domain containing 1

Synonyms

HBEBP3; HBEBP36; KIBRA; MEMRYQTL; PPP1R168;

Species

Homo sapiens

Ensembl Protein

ENSP00000265293

InnateDB Gene

IDBG-56833 (WWC1)

Protein Structure

UniProt Annotation

Function

Probable regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in tumor suppression by restricting proliferation and promoting apoptosis. Along with NF2 can synergistically induce the phosphorylation of LATS1 and LATS2 and can probably function in the regulation of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway. Acts as a transcriptional coactivator of ESR1 which plays an essential role in DYNLL1-mediated ESR1 transactivation. Regulates collagen-stimulated activation of the ERK/MAPK cascade. Modulates directional migration of podocytes. Acts as a substrate for PRKCZ. Plays a role in cognition and memory performance. {ECO:0000269PubMed:15081397, ECO:0000269PubMed:16684779, ECO:0000269PubMed:18190796, ECO:0000269PubMed:18596123, ECO:0000269PubMed:18672031, ECO:0000269PubMed:20159598, ECO:0000269PubMed:23778582}.

Subcellular Localization

Cytoplasm. Cytoplasm, perinuclear region. Nucleus. Cell projection, ruffle membrane. Note=Colocalizes with PRKCZ in the perinuclear region.

Disease Associations

Tissue Specificity

Expressed in mammary epithelial cells and breast cancer cell lines. Found in the luminal epithelium surrounding the ducts in the normal breast. In the brain, expressed in somatodendritic compartment of neurons in the cortex and hippocampus and in the cerebellum it is found in the Purkinje cells and some granule cells (at protein level). Detected in brain, heart, colon and kidney. In the kidney, expressed in glomerular podocytes, in some tubules and in the collecting duct. {ECO:0000269PubMed:12559952, ECO:0000269PubMed:18190796, ECO:0000269PubMed:18596123, ECO:0000269PubMed:18672031}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 26 experimentally validated interaction(s) in this database.

Experimentally validated
Total	26 [view]
Protein-Protein	26 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003713	transcription coactivator activity
GO:0005515	protein binding
GO:0019900	kinase binding
GO:0032947	protein complex scaffold

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006351	transcription, DNA-templated
GO:0016477	cell migration
GO:0030010	establishment of cell polarity
GO:0032386	regulation of intracellular transport
GO:0035329	hippo signaling
GO:0035330	regulation of hippo signaling
GO:0035331	negative regulation of hippo signaling
GO:0043410	positive regulation of MAPK cascade
GO:0046621	negative regulation of organ growth