InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: BAG1

Summary

InnateDB Protein

IDBP-56888.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BAG1

Protein Name

BCL2-associated athanogene

Synonyms

BAG-1; HAP; RAP46;

Species

Homo sapiens

Ensembl Protein

ENSP00000369026

InnateDB Gene

IDBG-56882 (BAG1)

Protein Structure

UniProt Annotation

Function

Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release. Inhibits the pro-apoptotic function of PPP1R15A, and has anti-apoptotic activity. Markedly increases the anti-cell death function of BCL2 induced by various stimuli. {ECO:0000269PubMed:12724406, ECO:0000269PubMed:9305631, ECO:0000269PubMed:9873016}.

Subcellular Localization

Isoform 1: Nucleus. Cytoplasm. Note=Isoform 1 localizes predominantly to the nucleus.Isoform 2: Cytoplasm. Nucleus. Note=Isoform 2 localizes to the cytoplasm and shuttles into the nucleus in response to heat shock.Isoform 4: Cytoplasm. Nucleus. Note=Isoform 4 localizes predominantly to the cytoplasm. The cellular background in which it is expressed can influence whether it resides primarily in the cytoplasm or is also found in the nucleus. In the presence of BCL2, localizes to intracellular membranes (what appears to be the nuclear envelope and perinuclear membranes) as well as punctate cytosolic structures suggestive of mitochondria.

Disease Associations

Tissue Specificity

Isoform 4 is the most abundantly expressed isoform. It is ubiquitously expressed throughout most tissues, except the liver, colon, breast and uterine myometrium. Isoform 1 is expressed in the ovary and testis. Isoform 4 is expressed in several types of tumor cell lines, and at consistently high levels in leukemia and lymphoma cell lines. Isoform 1 is expressed in the prostate, breast and leukemia cell lines. Isoform 3 is the least abundant isoform in tumor cell lines (at protein level). {ECO:0000269PubMed:9679980}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 94 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	94 [view]
Protein-Protein	86 [view]
Protein-DNA	5 [view]
Protein-RNA	0
DNA-DNA	3 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005057	receptor signaling protein activity
GO:0005515	protein binding
GO:0051087	chaperone binding

Biological Process

GO:0006915	apoptotic process
GO:0007166	cell surface receptor signaling pathway
GO:0035556	intracellular signal transduction
GO:0043066	negative regulation of apoptotic process
GO:0070389	chaperone cofactor-dependent protein refolding