Version 5.4
Homo sapiens Protein: RPP38
Summary
InnateDB Protein IDBP-56913.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RPP38
Protein Name ribonuclease P/MRP 38kDa subunit
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000367444
InnateDB Gene IDBG-56909 (RPP38)
Protein Structure
UniProt Annotation
Function Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. RPP38 may associate transiently with RNase P RNA as a factor involved in the transport of H1 RNA to the putative site of its assembly in the cell, the nucleolus.
Subcellular Localization Nucleus, nucleolus {ECO:0000305}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.
Experimentally validated
Total 20 [view]
Protein-Protein 18 [view]
Protein-DNA 0
Protein-RNA 2 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004526 ribonuclease P activity
GO:0005515 protein binding
Biological Process
GO:0008033 tRNA processing
GO:0090501 RNA phosphodiester bond hydrolysis
GO:0090502 RNA phosphodiester bond hydrolysis, endonucleolytic
Cellular Component
GO:0005634 nucleus
GO:0005655 nucleolar ribonuclease P complex
Protein Structure and Domains
PDB ID
InterPro IPR004038 Ribosomal protein L7Ae/L30e/S12e/Gadd45
IPR029064 50S ribosomal protein L30e-like
PFAM PF01248
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P78345
PhosphoSite PhosphoSite-P78345
TrEMBL Q5VUC3
UniProt Splice Variant
Entrez Gene 10557
UniGene Hs.94986
RefSeq XP_006717426
HUGO HGNC:30329
OMIM 606116
CCDS CCDS7108
HPRD 09360
IMGT
EMBL AK057006 AK223418 AL590365 BC029494 CH471072 CR541816 U77664
GenPept AAC51142 AAH29494 BAD97138 BAG51842 CAG46615 CAH73968 EAW86240 EAW86241

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca