Version 5.4
Homo sapiens Protein: AQR
Summary
InnateDB Protein IDBP-5694.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol AQR
Protein Name aquarius homolog (mouse)
Synonyms fSAP164; IBP160;
Species Homo sapiens
Ensembl Protein ENSP00000156471
InnateDB Gene IDBG-5692 (AQR)
Protein Structure
UniProt Annotation
Function Intron-binding spliceosomal protein required to link pre-mRNA splicing and snoRNP (small nucleolar ribonucleoprotein) biogenesis. Plays a key role in position-dependent assembly of intron-encoded box C/D small snoRNP, splicing being required for snoRNP assembly. May act by helping the folding of the snoRNA sequence. Binds to intron of pre-mRNAs in a sequence-independent manner, contacting the region between snoRNA and the branchpoint of introns (40 nucleotides upstream of the branchpoint) during the late stages of splicing. {ECO:0000269PubMed:16949364}.
Subcellular Localization Nucleus {ECO:0000269PubMed:16949364}. Note=Localizes to speckle-like regions of the nucleoplasm.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 31 experimentally validated interaction(s) in this database.
Experimentally validated
Total 31 [view]
Protein-Protein 30 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0000398 mRNA splicing, via spliceosome
Cellular Component
GO:0005634 nucleus
GO:0016020 membrane
GO:0071013 catalytic step 2 spliceosome
Protein Structure and Domains
PDB ID
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O60306
PhosphoSite PhosphoSite-O60306
TrEMBL A0A024R9L1
UniProt Splice Variant
Entrez Gene 9716
UniGene Hs.614463
RefSeq NP_055506
HUGO HGNC:29513
OMIM 610548
CCDS CCDS42013
HPRD 12468
IMGT
EMBL AB011132 BC036913 BC070379 BC108262 BC127111 BC127112 CH471125 EF553519
GenPept AAH36913 AAH70379 AAI08263 AAI27112 AAI27113 ABQ66265 BAA25486 EAW92320 EAW92321

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca