Version 5.4
Homo sapiens Protein: RBBP9
Summary
InnateDB Protein IDBP-57261.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RBBP9
Protein Name retinoblastoma binding protein 9
Synonyms BOG; RBBP10;
Species Homo sapiens
Ensembl Protein ENSP00000336866
InnateDB Gene IDBG-57259 (RBBP9)
Protein Structure
UniProt Annotation
Function May play a role in the transformation process due to its capacity to confer resistance to the growth-inhibitory effects of TGF-beta1 through interaction with retinoblastoma and the subsequent displacement of E2F-1.
Subcellular Localization Cytoplasm {ECO:0000269PubMed:12296629}. Nucleus {ECO:0000269PubMed:12296629}.
Disease Associations
Tissue Specificity Widely expressed. Expressed at higher levels in tumor tissues than in normal tissues.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0016787 hydrolase activity
Biological Process
GO:0008152 metabolic process
GO:0042127 regulation of cell proliferation
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR010662 Putative hydrolase RBBP9/YdeN
IPR029058 Alpha/Beta hydrolase fold
PFAM PF06821
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O75884
PhosphoSite PhosphoSite-O75884
TrEMBL
UniProt Splice Variant
Entrez Gene 10741
UniGene Hs.69330
RefSeq NP_006597
HUGO HGNC:9892
OMIM 602908
CCDS CCDS13136
HPRD 04217
IMGT
EMBL AF039564 AF237576 AL121893 AL832411 BC015938 CH471133
GenPept AAC63498 AAH15938 AAL83721 CAC11112 CAI46193 EAX10236 EAX10237 EAX10238

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca