Homo sapiens Protein: DRAP1
Summary
InnateDB Protein IDBP-58082.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DRAP1
Protein Name DR1-associated protein 1 (negative cofactor 2 alpha)
Synonyms NC2-alpha;
Species Homo sapiens
Ensembl Protein ENSP00000307850
InnateDB Gene IDBG-58078 (DRAP1)
Protein Structure
UniProt Annotation
Function The association of the DR1/DRAP1 heterodimer with TBP results in a functional repression of both activated and basal transcription of class II genes. This interaction precludes the formation of a transcription-competent complex by inhibiting the association of TFIIA and/or TFIIB with TBP. Can bind to DNA on its own. {ECO:0000269PubMed:8608938, ECO:0000269PubMed:8670811}.
Subcellular Localization Nucleus {ECO:0000305}.
Disease Associations
Tissue Specificity Ubiquitous. Highly expressed in adult testis, heart, skeletal muscle, pancreas and brain, and in fetal brain, liver and kidney. {ECO:0000269PubMed:8608938, ECO:0000269PubMed:8670811}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 35 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 35 [view]
Protein-Protein 34 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0003714 transcription corepressor activity
GO:0005515 protein binding
GO:0008134 transcription factor binding
GO:0043565 sequence-specific DNA binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0006351 transcription, DNA-templated
Cellular Component
GO:0005622 intracellular
GO:0005634 nucleus
Protein Structure and Domains
PDB ID
InterPro IPR003958 Transcription factor CBF/NF-Y/archaeal histone
IPR007125 Histone core
IPR009072 Histone-fold
PFAM PF00808
PF00125
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q14919
PhosphoSite PhosphoSite-Q14919
TrEMBL E9PQX9
UniProt Splice Variant
Entrez Gene 10589
UniGene
RefSeq NP_006433
HUGO HGNC:3019
OMIM 602289
CCDS CCDS8123
HPRD 03796
IMGT
EMBL AP006287 BC010025 U41843 X96506
GenPept AAB02192 AAH10025 CAA65358