InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: DRAP1

Summary

InnateDB Protein

IDBP-58082.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DRAP1

Protein Name

DR1-associated protein 1 (negative cofactor 2 alpha)

Synonyms

NC2-alpha;

Species

Homo sapiens

Ensembl Protein

ENSP00000307850

InnateDB Gene

IDBG-58078 (DRAP1)

Protein Structure

UniProt Annotation

Function

The association of the DR1/DRAP1 heterodimer with TBP results in a functional repression of both activated and basal transcription of class II genes. This interaction precludes the formation of a transcription-competent complex by inhibiting the association of TFIIA and/or TFIIB with TBP. Can bind to DNA on its own. {ECO:0000269PubMed:8608938, ECO:0000269PubMed:8670811}.

Subcellular Localization

Nucleus {ECO:0000305}.

Disease Associations

Tissue Specificity

Ubiquitous. Highly expressed in adult testis, heart, skeletal muscle, pancreas and brain, and in fetal brain, liver and kidney. {ECO:0000269PubMed:8608938, ECO:0000269PubMed:8670811}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 35 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	35 [view]
Protein-Protein	34 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003714	transcription corepressor activity
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0043565	sequence-specific DNA binding
GO:0046982	protein heterodimerization activity