InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SART1

Summary

InnateDB Protein

IDBP-58127.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SART1

Protein Name

squamous cell carcinoma antigen recognized by T cells

Synonyms

Ara1; HOMS1; SART1259; SNRNP110; Snu66;

Species

Homo sapiens

Ensembl Protein

ENSP00000310448

InnateDB Gene

IDBG-58125 (SART1)

Protein Structure

UniProt Annotation

Function

Plays a role in mRNA splicing as a component of the U4/U6-U5 tri-snRNP, one of the building blocks of the spliceosome. May also bind to DNA. {ECO:0000269PubMed:11350945}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:11350945, ECO:0000269PubMed:9449708}. Note=Found in the nucleus of mitogen- activated peripheral blood mononuclear cells (PBMCs), tumor cells, or normal cell lines, but not in normal tissues except testis and fetal liver or in unstimulated PBMCs, suggesting preferential expression in proliferating cells.

Disease Associations

Tissue Specificity

Ubiquitously expressed. {ECO:0000269PubMed:9449708}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 114 experimentally validated interaction(s) in this database.

Experimentally validated
Total	114 [view]
Protein-Protein	114 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0000387	spliceosomal snRNP assembly
GO:0000398	mRNA splicing, via spliceosome
GO:0007050	cell cycle arrest
GO:0045585	positive regulation of cytotoxic T cell differentiation
GO:0097193	intrinsic apoptotic signaling pathway

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005737	cytoplasm
GO:0005794	Golgi apparatus
GO:0005829	cytosol
GO:0015030	Cajal body
GO:0071013	catalytic step 2 spliceosome