InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: A4GNT

Summary

InnateDB Protein

IDBP-58155.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

A4GNT

Protein Name

alpha-1,4-N-acetylglucosaminyltransferase

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000236709

InnateDB Gene

IDBG-58153 (A4GNT)

Protein Structure

UniProt Annotation

Function

Necessary for the synthesis of type III mucin. Catalyzes the transfer of N-acetylglucosamine (GlcNAc) to core 2 branched O- glycans.

Subcellular Localization

Golgi apparatus membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.

Disease Associations

Tissue Specificity

Detected in stomach and pancreas.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008375	acetylglucosaminyltransferase activity
GO:0008378	galactosyltransferase activity

Biological Process

GO:0005975	carbohydrate metabolic process
GO:0006493	protein O-linked glycosylation
GO:0009101	glycoprotein biosynthetic process
GO:0050680	negative regulation of epithelial cell proliferation

Cellular Component

GO:0000139	Golgi membrane
GO:0005795	Golgi stack
GO:0016020	membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR007577 Glycosyltransferase, DXD sugar-binding motif
IPR007652 Alpha 1,4-glycosyltransferase domain

PFAM

PF04488
PF04572

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9UNA3

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

51146

UniGene

Hs.278960

RefSeq

NP_057245

HUGO

HGNC:17968

OMIM

CCDS

CCDS3097

HPRD

12390

IMGT

EMBL

AF141315 BC119639 BC119640

GenPept

AAD48406 AAI19640 AAI19641