Version 5.4
Homo sapiens Protein: NAV3
Summary
InnateDB Protein IDBP-583128.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NAV3
Protein Name neuron navigator 3
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000446132
InnateDB Gene IDBG-49197 (NAV3)
Protein Structure
UniProt Annotation
Function May regulate IL2 production by T-cells. May be involved in neuron regeneration. {ECO:0000269PubMed:16166283}.
Subcellular Localization Nucleus outer membrane {ECO:0000250}.
Disease Associations Note=A chromosomal aberration disrupting NAV3 has been found in patients with Sezary syndrome. Translocation t(12;18)(q21;q21.2).
Tissue Specificity Highly expressed in brain. Expressed at low levels in heart and placenta. Present in activated T-cells but not in resting T-cells (at protein level). Down-regulated in primary neuroblastoma. {ECO:0000269PubMed:12062803, ECO:0000269PubMed:12079279, ECO:0000269PubMed:15158073, ECO:0000269PubMed:16166283}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0017111 nucleoside-triphosphatase activity
Biological Process
GO:0008152 metabolic process
Cellular Component
GO:0005640 nuclear outer membrane
Protein Structure and Domains
PDB ID
InterPro IPR001715 Calponin homology domain
IPR003593 AAA+ ATPase domain
IPR003959 ATPase, AAA-type, core
IPR027417 P-loop containing nucleoside triphosphate hydrolase
PFAM PF00307
PF00004
PF07724
PF13304
PRINTS
PIRSF
SMART SM00033
SM00382
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8IVL0
PhosphoSite PhosphoSite-Q8IVL0
TrEMBL F8VZV4
UniProt Splice Variant
Entrez Gene 89795
UniGene Hs.655301
RefSeq NP_055718
HUGO HGNC:15998
OMIM 611629
CCDS CCDS41815
HPRD 10114
IMGT
EMBL AB023155 AC073571 AC073608 AC078822 AC090020 AC138331 AF397731 AJ488201
GenPept AAM73757 BAA76782 CAD32554

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca