InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MTHFD1

Summary

InnateDB Protein

IDBP-583253.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MTHFD1

Protein Name

methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase

Synonyms

MTHFC; MTHFD;

Species

Homo sapiens

Ensembl Protein

ENSP00000438588

InnateDB Gene

IDBG-9107 (MTHFD1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 61 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	61 [view]
Protein-Protein	54 [view]
Protein-DNA	7 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004329	formate-tetrahydrofolate ligase activity
GO:0004488	methylenetetrahydrofolate dehydrogenase (NADP+) activity
GO:0005524	ATP binding

Biological Process

GO:0009396	folic acid-containing compound biosynthetic process
GO:0055114	oxidation-reduction process

Cellular Component

Protein Structure and Domains

PDB ID

InterPro

IPR000559 Formate-tetrahydrofolate ligase, FTHFS
IPR000672 Tetrahydrofolate dehydrogenase/cyclohydrolase
IPR020630 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain
IPR020631 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF01268
PF00763
PF02882

PRINTS

PR00085

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite