InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CHERP

Summary

InnateDB Protein

IDBP-583315.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CHERP

Protein Name

calcium homeostasis endoplasmic reticulum protein

Synonyms

DAN16; SCAF6; SRA1;

Species

Homo sapiens

Ensembl Protein

ENSP00000439856

InnateDB Gene

IDBG-35639 (CHERP)

Protein Structure

UniProt Annotation

Function

Involved in calcium homeostasis, growth and proliferation. {ECO:0000269PubMed:10794731, ECO:0000269PubMed:12656674}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:10794731, ECO:0000269PubMed:12656674, ECO:0000269PubMed:8010949}. Cytoplasm, perinuclear region {ECO:0000269PubMed:10794731, ECO:0000269PubMed:12656674, ECO:0000269PubMed:8010949}. Endoplasmic reticulum {ECO:0000269PubMed:10794731, ECO:0000269PubMed:12656674, ECO:0000269PubMed:8010949}. Note=Distributed throughout the cytoplasm and also localizes to the perinuclear region of both human erythroleukemia (HEL) cells and Jurkat cells. Colocalizes with ITPR1. {ECO:0000269PubMed:10794731, ECO:0000269PubMed:12656674, ECO:0000269PubMed:8010949}.

Disease Associations

Tissue Specificity

Expressed in brain, placenta, lung, liver, kidney, pancreas, cardiac and skeletal muscle, and in cultured HEL and Dami cells. {ECO:0000269PubMed:10794731}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 76 experimentally validated interaction(s) in this database.

Experimentally validated
Total	76 [view]
Protein-Protein	75 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0003723	RNA binding
GO:0005515	protein binding
GO:0044325	ion channel binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006396	RNA processing
GO:0006874	cellular calcium ion homeostasis
GO:0007399	nervous system development
GO:0008285	negative regulation of cell proliferation
GO:0051209	release of sequestered calcium ion into cytosol
GO:0051533	positive regulation of NFAT protein import into nucleus