InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: HIF1A

Summary

InnateDB Protein

IDBP-583325.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HIF1A

Protein Name

hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)

Synonyms

bHLHe78; HIF-1A; HIF-1alpha; HIF1; HIF1-ALPHA; MOP1; PASD8;

Species

Homo sapiens

Ensembl Protein

ENSP00000437955

InnateDB Gene

IDBG-8510 (HIF1A)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 258 experimentally validated interaction(s) in this database.
They are also associated with 21 interaction(s) predicted by orthology.

Experimentally validated
Total	262 [view]
Protein-Protein	220 [view]
Protein-DNA	38 [view]
Protein-RNA	1 [view]
DNA-DNA	3 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	21 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000989	transcription factor binding transcription factor activity
GO:0001076	RNA polymerase II transcription factor binding transcription factor activity
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003705	RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
GO:0004871	signal transducer activity
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0019899	enzyme binding
GO:0019901	protein kinase binding
GO:0031625	ubiquitin protein ligase binding
GO:0035035	histone acetyltransferase binding
GO:0035257	nuclear hormone receptor binding
GO:0042826	histone deacetylase binding
GO:0043565	sequence-specific DNA binding
GO:0044212	transcription regulatory region DNA binding
GO:0046982	protein heterodimerization activity
GO:0046983	protein dimerization activity
GO:0051879	Hsp90 protein binding

Biological Process

GO:0001525	angiogenesis
GO:0001568	blood vessel development
GO:0001666	response to hypoxia
GO:0001755	neural crest cell migration
GO:0001837	epithelial to mesenchymal transition
GO:0001892	embryonic placenta development
GO:0001922	B-1 B cell homeostasis
GO:0001938	positive regulation of endothelial cell proliferation
GO:0001944	vasculature development
GO:0001947	heart looping
GO:0002052	positive regulation of neuroblast proliferation
GO:0002248	connective tissue replacement involved in inflammatory response wound healing
GO:0003151	outflow tract morphogenesis
GO:0003208	cardiac ventricle morphogenesis
GO:0006089	lactate metabolic process
GO:0006110	regulation of glycolytic process
GO:0006355	regulation of transcription, DNA-templated
GO:0006879	cellular iron ion homeostasis
GO:0007165	signal transduction
GO:0007219	Notch signaling pathway
GO:0007595	lactation
GO:0008542	visual learning
GO:0010468	regulation of gene expression
GO:0010573	vascular endothelial growth factor production
GO:0010575	positive regulation vascular endothelial growth factor production
GO:0010634	positive regulation of epithelial cell migration
GO:0010870	positive regulation of receptor biosynthetic process
GO:0014850	response to muscle activity
GO:0019896	axon transport of mitochondrion
GO:0021502	neural fold elevation formation
GO:0021987	cerebral cortex development
GO:0030154	cell differentiation
GO:0030502	negative regulation of bone mineralization
GO:0030949	positive regulation of vascular endothelial growth factor receptor signaling pathway
GO:0032007	negative regulation of TOR signaling
GO:0032364	oxygen homeostasis
GO:0032722	positive regulation of chemokine production
GO:0032909	regulation of transforming growth factor beta2 production
GO:0032963	collagen metabolic process
GO:0035162	embryonic hemopoiesis
GO:0035774	positive regulation of insulin secretion involved in cellular response to glucose stimulus
GO:0042127	regulation of cell proliferation
GO:0042541	hemoglobin biosynthetic process
GO:0042593	glucose homeostasis
GO:0042789	mRNA transcription from RNA polymerase II promoter
GO:0043066	negative regulation of apoptotic process
GO:0043524	negative regulation of neuron apoptotic process
GO:0043619	regulation of transcription from RNA polymerase II promoter in response to oxidative stress
GO:0045087	innate immune response (InnateDB)
GO:0045648	positive regulation of erythrocyte differentiation
GO:0045766	positive regulation of angiogenesis
GO:0045821	positive regulation of glycolytic process
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045926	negative regulation of growth
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0046716	muscle cell cellular homeostasis
GO:0046886	positive regulation of hormone biosynthetic process
GO:0048514	blood vessel morphogenesis
GO:0048546	digestive tract morphogenesis
GO:0050790	regulation of catalytic activity
GO:0051000	positive regulation of nitric-oxide synthase activity
GO:0051216	cartilage development
GO:0051541	elastin metabolic process
GO:0060574	intestinal epithelial cell maturation
GO:0061030	epithelial cell differentiation involved in mammary gland alveolus development
GO:0061298	retina vasculature development in camera-type eye
GO:0061418	regulation of transcription from RNA polymerase II promoter in response to hypoxia
GO:0061419	positive regulation of transcription from RNA polymerase II promoter in response to hypoxia
GO:0070101	positive regulation of chemokine-mediated signaling pathway
GO:0070243	regulation of thymocyte apoptotic process
GO:0070244	negative regulation of thymocyte apoptotic process
GO:0071347	cellular response to interleukin-1
GO:0071456	cellular response to hypoxia
GO:0071542	dopaminergic neuron differentiation
GO:2001054	negative regulation of mesenchymal cell apoptotic process

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005667	transcription factor complex
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0031514	motile cilium

Protein Structure and Domains

PDB ID

InterPro

IPR000014 PAS domain
IPR001321 Hypoxia-inducible factor-1 alpha
IPR001610 PAC motif
IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
IPR013655 PAS fold-3
IPR013767 PAS fold
IPR014887 HIF-1 alpha, transactivation domain, C-terminal
IPR021537 Hypoxia-inducible factor, alpha subunit

PFAM