InnateDB Protein
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IDBP-583756.3
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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PSMB5
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Protein Name
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proteasome (prosome, macropain) subunit, beta type, 5
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Synonyms
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LMPX; MB1; X;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000452424
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InnateDB Gene
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IDBG-2988 (PSMB5)
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Protein Structure
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Function |
The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This unit is responsible of the chymotrypsin-like activity of the proteasome and is one of the principal target of the proteasome inhibitor bortezomib. May catalyze basal processing of intracellular antigens. Plays a role in the protection against oxidative damage through the Nrf2-ARE pathway (By similarity). {ECO:0000250}.
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Subcellular Localization |
Cytoplasm. Nucleus.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 111 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated |
Total |
111
[view]
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Protein-Protein |
108
[view]
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Protein-DNA |
3
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
6 [view]
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Molecular Function |
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Biological Process |
GO:0000082
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G1/S transition of mitotic cell cycle
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GO:0000209
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protein polyubiquitination
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GO:0000278
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mitotic cell cycle
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GO:0002474
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antigen processing and presentation of peptide antigen via MHC class I
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GO:0002479
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antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
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GO:0006521
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regulation of cellular amino acid metabolic process
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GO:0006915
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apoptotic process
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GO:0006977
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DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
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GO:0010467
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gene expression
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GO:0016032
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viral process
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GO:0016070
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RNA metabolic process
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GO:0016071
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mRNA metabolic process
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GO:0031145
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anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
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GO:0034641
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cellular nitrogen compound metabolic process
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GO:0042590
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antigen processing and presentation of exogenous peptide antigen via MHC class I
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GO:0042981
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regulation of apoptotic process
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GO:0043066
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negative regulation of apoptotic process
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GO:0044281
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small molecule metabolic process
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GO:0051436
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negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
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GO:0051437
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positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
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GO:0051439
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regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
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GO:0051603
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proteolysis involved in cellular protein catabolic process
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Cellular Component |
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PDB ID |
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InterPro |
IPR001353
Proteasome, subunit alpha/beta
IPR029055
Nucleophile aminohydrolases, N-terminal
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PFAM |
PF00227
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
P28074
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PhosphoSite |
PhosphoSite-P28074
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
5693
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UniGene |
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RefSeq |
NP_001138404
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HUGO |
HGNC:9542
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OMIM |
600306
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CCDS |
CCDS45084
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HPRD |
02629
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IMGT |
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EMBL |
AK300714
AK311895
AL132780
BC004146
BC057840
BC107720
BT006777
BX248299
BX538001
CD048996
CH471078
D29011
S74378
X95586
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GenPept |
AAB33092
AAH57840
AAI07721
AAP35423
BAA06097
BAG34836
BAG62391
CAA64838
CAD62626
CAD97956
EAW66193
EAW66195
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