Version 5.4
Homo sapiens Protein: ADPRM
Summary
InnateDB Protein IDBP-583851.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ADPRM
Protein Name chromosome 17 open reading frame 48
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000431622
InnateDB Gene IDBG-30673 (ADPRM)
Protein Structure
UniProt Annotation
Function Hydrolyzes ADP-ribose, IDP-ribose, CDP-glycerol, CDP- choline and CDP-ethanolamine, but not other non-reducing ADP- sugars or CDP-glucose. May be involved in immune cell signaling as suggested by the second-messenger role of ADP-ribose, which activates TRPM2 as a mediator of oxidative/nitrosative stress (By similarity). {ECO:0000250}.
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0046872 metal ion binding
GO:0047631 ADP-ribose diphosphatase activity
GO:0047734 CDP-glycerol diphosphatase activity
Biological Process
GO:0008152 metabolic process
Cellular Component
Protein Structure and Domains
PDB ID
InterPro IPR029052 Metallo-dependent phosphatase-like
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q3LIE5
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 56985
UniGene Hs.594579
RefSeq
HUGO HGNC:30925
OMIM
CCDS
HPRD 17473
IMGT
EMBL AB073393 AF168715 AK292629 BC001294 BC070155 CH471108
GenPept AAF87317 AAH01294 AAH70155 BAE45723 BAF85318 EAW89995 EAW89996

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca