InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CD3G

Summary

InnateDB Protein

IDBP-584276.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CD3G

Protein Name

CD3g molecule, gamma (CD3-TCR complex)

Synonyms

CD3-GAMMA; IMD17; T3G;

Species

Homo sapiens

Ensembl Protein

ENSP00000431445

InnateDB Gene

IDBG-73647 (CD3G)

Protein Structure

UniProt Annotation

Function

The CD3 complex mediates signal transduction.

Subcellular Localization

Membrane; Single-pass type I membrane protein.

Disease Associations

Immunodeficiency 17 (IMD17) [MIM:615607]: An autosomal recessive primary immunodeficiency characterized by highly variable clinical severity. Some patients have onset of severe recurrent infections in early infancy that may be lethal, whereas others may be only mildly affected or essentially asymptomatic into young adulthood. More severely affected patients may have evidence of autoimmune disease or enteropathy. The immunologic pattern is similar among patients, showing partial T-cell lymphopenia, decreased amounts of the CD3 complex, and impaired proliferative responses to T-cell receptor dependent stimuli. The phenotype in some patients is reminiscent of severe combined immunodeficiency. {ECO:0000269PubMed:1635567, ECO:0000269PubMed:17277165}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	11 [view]
Protein-Protein	7 [view]
Protein-DNA	4 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004888	transmembrane signaling receptor activity
GO:0005515	protein binding
GO:0030159	receptor signaling complex scaffold activity
GO:0042608	T cell receptor binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0006461	protein complex assembly
GO:0007163	establishment or maintenance of cell polarity
GO:0007166	cell surface receptor signaling pathway
GO:0015031	protein transport
GO:0031295	T cell costimulation
GO:0038096	Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0042110	T cell activation
GO:0045087	innate immune response
GO:0050776	regulation of immune response
GO:0050852	T cell receptor signaling pathway
GO:0070228	regulation of lymphocyte apoptotic process

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0042101	T cell receptor complex
GO:0042105	alpha-beta T cell receptor complex