InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PRSS3

Summary

InnateDB Protein

IDBP-58429.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PRSS3

Protein Name

protease, serine, 3

Synonyms

MTG; PRSS4; T9; TRY3; TRY4;

Species

Homo sapiens

Ensembl Protein

ENSP00000340889

InnateDB Gene

IDBG-58425 (PRSS3)

Protein Structure

UniProt Annotation

Function

Digestive protease specialized for the degradation of trypsin inhibitors. In the ileum, may be involved in defensin processing, including DEFA5. {ECO:0000269PubMed:12021776, ECO:0000269PubMed:14507909}.

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

Expressed in pancreas and brain. Also expressed in Paneth cells, at the base of small intestinal crypts. {ECO:0000269PubMed:12021776}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004252	serine-type endopeptidase activity
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0008236	serine-type peptidase activity

Biological Process

GO:0006508	proteolysis
GO:0006766	vitamin metabolic process
GO:0006767	water-soluble vitamin metabolic process
GO:0007586	digestion
GO:0009235	cobalamin metabolic process
GO:0031638	zymogen activation
GO:0043542	endothelial cell migration
GO:0044281	small molecule metabolic process
GO:0045087	innate immune response