InnateDB Protein
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IDBP-58433.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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PRSS3
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Protein Name
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protease, serine, 3
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Synonyms
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MTG; PRSS4; T9; TRY3; TRY4;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000368715
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InnateDB Gene
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IDBG-58425 (PRSS3)
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Protein Structure
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Function |
Digestive protease specialized for the degradation of trypsin inhibitors. In the ileum, may be involved in defensin processing, including DEFA5. {ECO:0000269PubMed:12021776, ECO:0000269PubMed:14507909}.
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Subcellular Localization |
Secreted.
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Disease Associations |
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Tissue Specificity |
Expressed in pancreas and brain. Also expressed in Paneth cells, at the base of small intestinal crypts. {ECO:0000269PubMed:12021776}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
6
[view]
|
Protein-Protein |
6
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR001254
Peptidase S1
IPR001314
Peptidase S1A, chymotrypsin-type
IPR009003
Trypsin-like cysteine/serine peptidase domain
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PFAM |
PF00089
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PRINTS |
PR00722
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PIRSF |
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SMART |
SM00020
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TIGRFAMs |
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Modification |
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SwissProt |
P35030
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PhosphoSite |
PhosphoSite-P35030
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
5646
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UniGene |
|
RefSeq |
NP_002762
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HUGO |
HGNC:9486
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OMIM |
613578
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CCDS |
CCDS6545
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HPRD |
06685
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IMGT |
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EMBL |
AB298285
AB298286
AF029308
AL139113
AL356489
AL358573
BC069476
BC069494
CH471071
D45417
X15505
X71345
X72781
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GenPept |
AAC13322
AAH69476
AAH69494
BAA08257
BAF80324
BAF80325
CAA33527
CAA50484
CAB58178
EAW58482
EAW58484
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